CUX1 gene mutations linked to tumour growth

A new study from the Sanger Institute (Wong CC et al. Nature Genetivs, 2013) found that CUX1 is mutated at a relatively low frequency, but across many different types of cancer.

CancerIndex has added a page: http://www.cancerindex.org/geneweb/CUX1.htm

The study used genetic data from over 7,600 cancer patients, collected and sequenced by the International Cancer Genome Constortium (ICGC) and other groups. Theyfound that when CUX1 is deactivated, it had a knock-on effect on a biological inhibitor, PIK3IP1, reducing its inhibitory effects. This mobilises an enzyme responsible for cell growth, phosphoinositide 3-kinase (PI3K), increasing the rate of tumour progression.

See more at: http://www.cancerindex.org/geneweb/CUX1.htm

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